A new peer-reviewed paper in the journal Bioscience draws attention to potential hazards on nontarget species of pesticides and GMOs made with RNA-interference (RNAi) gene-silencing techniques. These hazards could include off-target gene silencing or immune stimulation.
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RNAi-Based Insecticidal Crops: Potential Effects on Nontarget Species
Authors: Jonathan G. LundGren and Jian J. Duan (USDA Agricultural Research Service)
The potential hazards posed by RNA interference (RNAi)–based pesticides and genetically modified crops to nontarget organisms include off-target gene silencing, silencing the target gene in unintended organisms, immune stimulation, and saturation of the RNAi machinery. Nontarget organisms will vary in their exposure to small RNAs produced by genetically modified crops at a previously unrealized scale. Areas that warrant future work include the persistence of insecticidal small RNAs in the environment, describing crop-based food webs to understand those species that are most exposed, sequencing genomes for species to proactively understand those that may be affected by RNAi, and substantiating that laboratory toxicity testing can accurately predict the field-level effects of this technology. The costs and benefits of pesticidal RNA must be considered relative to current pest management options as pesticidal RNAs move from a theoretical approach to being used as a practical tool.